(48) Effectiveness of HPV Self-sampling on Participation in Cervical Cancer Screening: A Scoping Review

Ms. Ho-Yan WONG¹, Prof. Eliza LY WONG^2
1The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong SAR, ²The Jockey Club School of Public Health and Primary Care Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR

Background
HPV testing has been recognized as a feasible and effective approach in cervical cancer screening, especially for non-attendees. However, existing evidence showed the effectiveness of self-collected HPV testing on screening participation is controversial. This scoping review aims to summarize existing findings and identify to what extent offering HPV self-sampling kit leads to increased screening participation among non-attendees.

Method
A systematic literature search conducted in databases PubMed and Embase in May 2020 identified articles examining the effectiveness of HPV self-sampling on cervical cancer screening participation. Search results were limited by the following criteria: 1) randomized controlled trials, 2) primary studies, 3) English language and 4) publication from 2010 to 2020.

Results
A total of 112 articles were identified. 15 articles were included for a full review after excluding for studies with unmet criteria and duplications. Of these studies, 8 (53.3%) from Europe, 6 (40%) from North America, and 1 (6.67%) from Asia. This review affirms that HPV self-sampling is a feasible and acceptable screening approach. It highlighted that offering HPV kit is more effective to increase screening participation compared to clinical reminders for either cervical cytology or self-collected HPV testing. For screening preferences, women generally opted for HPV self-sampling than conventional cytology smear, especially for those under-screened and never screened. In addition, direct mailing HPV self-sampling kits was found as an efficient and cost-effective way to improve screening participation in comparison to the invitation to HPV self-sampling as an opt-in approach.

Conclusion
HPV self-sampling has been demonstrated as a promising approach to improve participation in cervical cancer screening, especially among those non-attendees. The delivery approach of self-sampling kits should be considered when implementing HPV testing into local screening practice in the future.

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